A Deep Dive into the ECS: Our Bodies’ Master Regulator

When it comes to understanding the many benefits people experience from CBD oil, learning about the Endocannabinoid System (ECS) is essential.

The ECS plays an essential role in our well-being by regulating our mood, sleep, stress, appetite, memory, immune function and much more. An intricate network of receptors, endocannabinoids and enzymes are involved in this master regulating system. Together, they make sure that we maintain a crucial balance and sense of harmony within our bodies.

Going forward, we’re strictly going to dive into the biology of the ECS and the fascinating ways in which it works. If you’d rather have a more all-around introduction to it, with some political and social context, we suggest reading this article instead.

How Does the ECS Keep Us in Balance?

The ECS consists of three key components: receptors, endocannabinoids, and enzymes. 

Let’s explore each of these components and how they work together.

  1. Receptors: “Receiving & Transmitting Signals”

The ECS relies on two primary receptors: CB1 and CB2. CB1 receptors are mainly found in the brain and central nervous system, while CB2 receptors reside in peripheral tissues and immune cells. These receptors act as gatekeepers that receive and transmit signals to bring about physiological changes. 

For instance, CB1 receptor activation plays a role in managing mood and emotions, potentially affecting anxiety and depression. Whereas CB2 receptor activation can lead to decreased inflammation and may contribute to managing inflammatory conditions.

  1. Endocannabinoids: “Messengers of Harmony”

Endocannabinoids are naturally occurring compounds within our bodies that bind to cannabinoid receptors, like CB1 and CB2. The two most studied endocannabinoids are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). Each endocannabinoid has a distinctive role: Anandamide helps regulate mood, pain, and appetite, while 2-AG influences immune responses and neuroprotection

Research has also shown that the “runner’s high” experience after exercise has been shown to be induced in part by anandamide acting on CB1 receptors, eliciting anxiolytic effects on the body. 

  1. Enzymes: “Fine-Tuning the Balance”

Enzymes help to maintain optimal levels of endocannabinoids by orchestrating the synthesis, release, and degradation of endocannabinoids. For instance, fatty acid amide hydrolase (FAAH) breaks down anandamide, while monoacylglycerol lipase (MAGL) metabolises 2-AG. These enzymes ensure that endocannabinoid levels are balanced and appropriately maintained throughout the body.

These three components are the basis for the endocannabinoid system: a sophisticated regulatory system responsible for achieving homeostasis, or a sense of balance, within our bodies. 

The ECS does this by being in close connection with the many physiological processes that sustain our bodies throughout the day, e.g. sleep or digestion. When a disturbance occurs in any of these physiological processes, the ECS detects it and kicks into action, working hard to restore their equilibriums. In a way, you can think of the ECS as having an “observer” role over every process, making sure that everything is running smoothly.

The endocannabinoid system is almost no different to our nervous system; they both send signals between different cells and organs, in a way, tying everything together and ensuring our intricate physiological network remains well-connected and functioning optimally. The nervous system is a master communicator, and the ECS is (also) a master regulator.

The ECS isn’t Perfect – but CBD Can Assist

Like almost anything, the ECS can also not be working as it should. There is even a condition termed “Endocannabinoid Deficiency” which is, essentially, a shortage in the production of the endocannabinoids that are necessary to get the ECS working optimally. However, it doesn’t need to go that far before we start thinking about nurturing and optimising our ECS.

There are several ways to assist the ECS in its optimisation and CBD is one of them. CBD, or cannabidiol, found abundantly in CBD oil, fascinatingly interacts with the ECS.

CBD is thought to modulate the activity of the endocannabinoid system, but it doesn’t bind directly to the CB1 or CB2 receptors. Instead, it’s thought to work by preventing the breakdown of the body’s naturally produced endocannabinoids, increasing their availability and enhancing their effect. It may also interact with other receptors such as TRPV1 receptors that are known to mediate pain perception, inflammation and body temperature.

What More Can We Expect from Science and the ECS?

We already know that the ECS has a significant role in our well-being. We also know that there is still much left to discover on this fascinating topic. 

You see, unfortunately, the research into the ECS was relatively held back since its groundbreaking discovery in the late 80s.

Why?

Well, it just happened to be that it was because of research looking into the impact that Cannabis had on our bodies that the ECS was discovered for the first time – at a time when politics were particularly sensitive about the topic of Cannabis. Since then, the ECS (and hemp) has often been falling under the same umbrella. But perhaps it’s time to give our endocannabinoid systems a better second look, considering how much it’s doing for our well-being.

In addition to the well-known anandamide and 2-AG, researchers are exploring novel endocannabinoids, learning about their unique roles and the different actions they have in the body. An improved comprehension of these signalling compounds, which we naturally produce, will allow us to better gauge and possibly manage the therapeutic potential of the ECS.

There are also ongoing studies that are currently defining ECS’s involvement in various diseases like chronic pain, neurodegenerative diseases, psychiatric disorders, metabolic disorders, and immune-related ailments. Needless to say, this could improve our potential for therapeutic interventions, as well.

Terpenes and flavonoids, other prominent compounds found in hemp, are also being studied for their interactions with the ECS, holding further therapeutic promise. 

Finally, once we get a greater general understanding of the ECS, we’ll then also be better able to distinguish the individual variations that are in each of our endocannabinoid systems, allowing for more personalised medical approaches.

What we’re trying to say is that this might just be the tip of the iceberg!

Giving the ECS a Chance is Giving our Well-Being a Chance

There’s no doubt that the endocannabinoid system is a remarkable network playing a crucial role in our well-being. Understanding its components and functions helps us appreciate the significant role of how CBD oil works and its potential to support balance and harmony within our bodies.

However, due to its somewhat coincidental affiliation with cannabis, scientific research was relatively held back on the ECS. We hope we can get past the undeserved social stigma, so we’re sooner able to discover more about this system holding valuable insights into our well-being.

If we, at LAYV, want to support the social and scientific advancements of the endocannabinoid system, we also need to represent strong business conduct which includes high-quality products and services – and because high-quality CBD products are certainly necessary if we all want to get the most out of our endocannabinoid systems!

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What LAYV® users say

Loes-chanLoes-chan
14:01 13 Mar 24
I bought the CBD oil on the recommendation of a friend who was very satisfied with it. I think it's a nice oil! I don't notice much of the effects, but I do sleep a little better since I started using it so I'm satisfied :)
Diewertje van BavelDiewertje van Bavel
20:41 07 Feb 24
Great product. It helps me with my pain and stress complaints. It also makes me sleep a lot better. I can really recommend this product!
Lilian DibbetsLilian Dibbets
16:28 15 Jan 24
This really is a fantastic product. I was always a good sleeper, but with this CBD oil (20%) I sleep much deeper and wake up rested. In addition, it helps to calm my nervous system and I am much calmer and focused throughout the day. I recommend this product to everyone for a calm nervous system and good health. Think of it as a nutritional supplement that should not be missing in this hectic Western world we live in.
Richard LemmensRichard Lemmens
10:44 18 Dec 23
What a fantastic product. For several months now we have been using the LAYV CBD variant 20% daily before going to sleep as a routine. As young parents, sleep is sacred to us, but with children this is sometimes lacking. By using the 20% variant, we both notice that we sleep much deeper, making us more rested in the morning.We also use the drug when we experience a stressful situation. By using a few drops, we quickly notice that we become calmer and can continue with our busy daily work lives.Previously used products from other brands, but these do not provide a pleasant mouthfeel and the taste is not as mild as the LAYV variant.
Fabiana FiniFabiana Fini
17:41 04 Dec 23
Liesbeth MekkeringLiesbeth Mekkering
10:14 14 Nov 23
I slept wonderfully thanks to LAYV, I couldn't live without it
Tahsin BulbulTahsin Bulbul
07:22 30 Oct 23
Juan Calixto morelloJuan Calixto morello
13:13 29 Oct 23
I recently no longer suffer from sleepless nights thanks to layv!
Nikos VasilatosNikos Vasilatos
17:19 25 Jun 23
Happy with the product, the responsiveness of the Layv team and the smooth delivery. Recommended!
Michal SokolowskiMichal Sokolowski
21:05 15 Jun 23
Excellent oils, quick contact if you have any questions, fast shipping abroad, I recommend! Greetings from Poland!
Charles PierrepontCharles Pierrepont
17:31 05 Apr 23
The LAYV CBD extract tastes and feels very clean. Dealing with the team at LAYV has been a pleasure. For someone who travels a lot, the clean CBD extract absolutely helps to unwind at the end of a long day.
Clare La Feber-ToolisClare La Feber-Toolis
06:24 30 Mar 23
I used the 5% LAYV CBD to manage pain from the symptoms of arthritis and it really helps. It has completely reduced the need for strong painkillers which is great. I also take a couple of drops of CBD if I feel stressed or overwhelmed and it calms me down. Highly recommend this CBD oil.
Runa WynekenRuna Wyneken
11:58 28 Sep 22
Love this product and the brand! Totally recommend it! Cleanest CBD out there!
Sven HurksSven Hurks
10:33 15 Jun 22
I have been using LAYV CBD for over one year, improving my sleep quality significantly.
Maria Mora GarciaMaria Mora Garcia
13:12 30 Apr 22
Excellent.I really like this cbd oil.
C. R.C. R.
21:44 25 Mar 22
After trying several other CBD oils, I've found my favourite. LAYV's cbd oil helps me with sleep and menstrual pain, taste is the best I've tried, great quality flask/packaging... Support is fast, professional and very helpful for any question! Even a handwritten note when you order from them!! Solid throughout. A CBD brand that's here to stay, finally!
Caspar de KlerCaspar de Kler
13:18 17 Apr 24
Top kwaliteit, goede klantenservice
Loes-chanLoes-chan
14:01 13 Mar 24
Ik heb de cbd olie gekocht op aanraden van vriendin die er heel erg tevreden over was. Ik vind het fijne olie! Ik merk niet megaveel van de effecten maar ik slaap wel iets beter sinds ik het gebruik dus ik ben tevreden :)
Diewertje van BavelDiewertje van Bavel
20:41 07 Feb 24
Geweldig product. Het helpt me bij mijn pijn en stressklachten. Ook slaap ik er een stuk beter door. Ik kan dit product echt aanraden!
Lilian DibbetsLilian Dibbets
16:28 15 Jan 24
Dit is echt een fantastisch product. Ik was altijd een goede slaper maar met deze CBD olie (20%) slaap ik veel dieper en wordt ik uitgerust wakker. Daarnaast helpt het mijn zenuwstelsel tot rust te brengen en ben ik door de dag heen veel rustiger en gefocussed. Ik raad iedereen dit product aan voor een kalm zenuwustelsel en een goede gezondheid. Zie het als een voedingsupplement die niet mag ontbreken in deze hectische westerse wereld waar we in leven.
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Tom
@tomdima0711
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We (my wife and I) love this product. We use it to relax and unwind in the evening for a better night's sleep. We both noticed that our stress levels dropped significantly.....
Ferdinand van der Neut
@ketschi.a
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LAYV's CBD oil provides more structure to my thinking throughout the day. In the process, it greatly improves the quality of my sleep with just a few drops a day. Can't say anything but highly recommended!
Sophie
@carolinesophiew
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I really love this product! It helps me with anxiety, confidence, relaxation and pain relief. My advice would be to take a few drops every day so that it can be absorbed into the bloodstream and you can enjoy the long-term benefits. 1000% recommended!
Kas van Vliet
@kasvanvliet
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Calming without the risk of paranoia. I used to reach for cannabis on very sporadic frequencies to unload from a busy existence as an entrepreneur and journalist, but smoking weed or hash was always a gamble for me: 50/50 chance of a slightly paranoid experience that exacerbated stress rather than reduced it. For me, this is a good substitute that allows me to relax physically and mentally, but sin negative high. But don't think of it as a panacea; you have to create a peaceful environment for it to really come into its own.
Alexandra
@angelique_acc
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I bought a bottle at Jumbo today, because I am always very cramped and tense, and suffer a lot from headaches and stress..... i must say i am pleasantly surprised, that t is sold by jumbo, and that t works! Definitely worth a try! Am curious if there will be more products from you.
H. Paulus de Groot
@hnkdgrt
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Have been using this for months for chronic pain in my shoulder, and it just works!
jl_arellanocamacho
@jl_arellanocamacho
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The product has a good taste despite its high concentration (500 mg). It helps me with stress, sleep and pain.
Willem Spoor
@w.spoor35
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Helps excellent against osteoarthritis pain
Maria
@maria.mgj
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Good product and good minty taste
J.A. Worskasan
@jaworskasan
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Layv Cbd oil makes me calmer, it helps me with livedo reticularis on my legs, after using it my legs become normal again. I used CBD from other brands and Layv Cbd oil is definitely the highest quality product.
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