Pain Pt. 2: What Science Says About CBD’s Ability to Manage Pain

In Part One, we got a clearer idea of pain: what it is, its probable causes, how it impacts us individually and how we’re dealing with it socially.

Now, we’ll be focusing on CBD’s potential as a natural solution for pain management. 

What Science Says About Your CBD Experience

The interest in CBD’s potential therapeutic effects has grown substantially since the early 2000s, especially following the legalisation of medical and recreational cannabis in certain parts of the world. Pain management is one of the most studied applications of CBD, along with its potential use for epilepsy, anxiety and sleep disorders.

Here you can find some common causes of pain and what’s been researched about them in the world of CBD science:

  1. Inflammatory Conditions & CBD Oil: Inflammatory conditions, such as arthritis, can cause chronic pain due to ongoing inflammation in the affected joints. 

A 2017 study investigated the effects of CBD on osteoarthritic pain in rats. The researchers found that CBD reduced joint pain and inflammation without causing notable side effects. While this study shows promise, further research is necessary to determine the efficacy and safety of CBD for arthritis pain in humans.

  1. Neuropathic Pain & CBD Oil: Neuropathic pain is caused by nerve damage and can be challenging to treat. It’s often characterized by tingling, burning, or shooting sensations. Conditions like diabetic neuropathy and postherpetic neuralgia can cause persistent discomfort. 

A study published in 2020 investigated the effects of CBD on neuropathic pain in rats. The researchers found that CBD administration reduced pain responses in the animals and concluded that CBD may have therapeutic potential for neuropathic pain management. However, further research is needed to validate these results in human studies.

  1. Headaches and Migraines & CBD Oil: Headaches, including tension headaches and migraines, are common sources of pain that can significantly impact daily life. 

CBD oil’s potential analgesic and anti-inflammatory properties have attracted attention in the realm of headache management. By potentially reducing inflammation and alleviating pain perception, CBD oil may offer a natural alternative for those seeking relief from headaches and migraines.

  1. Musculoskeletal Pain & CBD Oil: Musculoskeletal pain can arise from various causes, such as strains, sprains, or overuse injuries. 

CBD oil’s potential analgesic and anti-inflammatory effects may offer a holistic approach to managing musculoskeletal pain. By potentially reducing pain and supporting the body’s natural healing processes, CBD oil may be a valuable addition to a pain management regimen for those dealing with musculoskeletal discomfort.

  1. Chronic Pain & CBD Oil: A 2020 systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated the use of CBD for chronic pain management. 

The analysis included 29 studies with a total of 2,907 participants. The researchers found that CBD was associated with a significant reduction in pain scores compared to placebo. However, they noted that more high-quality studies are needed to confirm these findings. 

6. Cancer-Related Pain & CBD Oil: Cancer patients often experience pain as a result of the disease itself or its treatments. A study published in 2010 in the Journal of Pain and Symptom Management investigated the use of an oral spray containing both THC (tetrahydrocannabinol) and CBD for cancer-related pain. The study found that the spray significantly improved pain management compared to a placebo, suggesting that a combination of cannabinoids, including CBD, could have potential in alleviating cancer-related pain.

7. Multiple Sclerosis (MS) Pain & CBD Oil: Neuropathic pain is common in individuals with multiple sclerosis (MS). A study published in 2012 in the European Journal of Pain examined the effects of CBD on neuropathic pain in MS patients. The researchers found that CBD treatment reduced pain and improved sleep quality in participants, indicating that CBD might offer relief for neuropathic pain associated with MS.

8. Fibromyalgia Pain & CBD Oil: Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal pain and tenderness. A study published in 2019 in the journal Pain Medicine investigated the effects of CBD on fibromyalgia-related pain. Participants who used CBD reported a significant reduction in pain intensity and improved quality of life. However, the study had a small sample size, highlighting the need for larger-scale research to validate these findings.

9. Postoperative Pain & CBD Oil: After surgery, postoperative pain can be a challenge to manage. A study published in 2021 in the journal Medicina (Kaunas) examined the effects of CBD on postoperative pain in patients undergoing major abdominal surgery. The researchers found that CBD treatment was associated with reduced pain scores and decreased opioid consumption in the CBD group compared to the control group.

10. Temporomandibular Disorder (TMD) Pain & CBD Oil: Temporomandibular disorders (TMD) can lead to jaw pain and discomfort. A study published in 2021 in the Journal of Clinical Medicine investigated the effects of CBD on TMD-related pain. Participants who applied a CBD gel to the affected area reported significant reductions in pain intensity and improved jaw function compared to a placebo group.

Essentially, CBD works by interacting with our endocannabinoid systems (ECS), a physiological system that regulates our sleep, mood, appetite, pain, and much more (read our dedicated article on the fascinating ECS here). 

CBD is believed to interact with various receptors included in the ECS, such as cannabinoid receptors (CB1 and CB2), which are involved in pain regulation. A 2018 review article discussed the interaction of CBD with these receptors and its potential analgesic effects. The authors highlighted that CBD has complex mechanisms of action and can modulate pain perception through multiple pathways.

It’s important to note that the field of CBD research is still relatively young, and while there is growing interest in understanding its effects on pain, there is still much to discover. The available studies on CBD and pain tend to be limited in size and have variations in study design.

Nonetheless, the potential of CBD as an analgesic has prompted increased scientific interest and ongoing research, focusing on understanding its mechanisms of action and exploring its potential applications in various pain conditions.

Staying Informed on CBD’s Ability to Assist in Pain Management

In this two-part series, we explored the fascinating yet somewhat ambiguous world of pain, its underlying mechanisms, and the potential role of CBD in pain management. 

If you’re looking forward to discovering more about this topic, feel free to subscribe to our newsletter where we can make sure to keep you up-to-date. By staying informed about the latest CBD research, we hope you can keep making even more informed decisions about using CBD oil as a natural approach to assist in your pain management.

Stay up-to-date with LAYV’s mission: subscribe to our Newsletter and join our Community.

What LAYV® users say

14:01 13 Mar 24
I bought the CBD oil on the recommendation of a friend who was very satisfied with it. I think it's a nice oil! I don't notice much of the effects, but I do sleep a little better since I started using it so I'm satisfied :)
Diewertje van BavelDiewertje van Bavel
20:41 07 Feb 24
Great product. It helps me with my pain and stress complaints. It also makes me sleep a lot better. I can really recommend this product!
Lilian DibbetsLilian Dibbets
16:28 15 Jan 24
This really is a fantastic product. I was always a good sleeper, but with this CBD oil (20%) I sleep much deeper and wake up rested. In addition, it helps to calm my nervous system and I am much calmer and focused throughout the day. I recommend this product to everyone for a calm nervous system and good health. Think of it as a nutritional supplement that should not be missing in this hectic Western world we live in.
Richard LemmensRichard Lemmens
10:44 18 Dec 23
What a fantastic product. For several months now we have been using the LAYV CBD variant 20% daily before going to sleep as a routine. As young parents, sleep is sacred to us, but with children this is sometimes lacking. By using the 20% variant, we both notice that we sleep much deeper, making us more rested in the morning.We also use the drug when we experience a stressful situation. By using a few drops, we quickly notice that we become calmer and can continue with our busy daily work lives.Previously used products from other brands, but these do not provide a pleasant mouthfeel and the taste is not as mild as the LAYV variant.
Fabiana FiniFabiana Fini
17:41 04 Dec 23
Liesbeth MekkeringLiesbeth Mekkering
10:14 14 Nov 23
I slept wonderfully thanks to LAYV, I couldn't live without it
Tahsin BulbulTahsin Bulbul
07:22 30 Oct 23
Juan Calixto morelloJuan Calixto morello
13:13 29 Oct 23
I recently no longer suffer from sleepless nights thanks to layv!
Nikos VasilatosNikos Vasilatos
17:19 25 Jun 23
Happy with the product, the responsiveness of the Layv team and the smooth delivery. Recommended!
Michal SokolowskiMichal Sokolowski
21:05 15 Jun 23
Excellent oils, quick contact if you have any questions, fast shipping abroad, I recommend! Greetings from Poland!
Charles PierrepontCharles Pierrepont
17:31 05 Apr 23
The LAYV CBD extract tastes and feels very clean. Dealing with the team at LAYV has been a pleasure. For someone who travels a lot, the clean CBD extract absolutely helps to unwind at the end of a long day.
Clare La Feber-ToolisClare La Feber-Toolis
06:24 30 Mar 23
I used the 5% LAYV CBD to manage pain from the symptoms of arthritis and it really helps. It has completely reduced the need for strong painkillers which is great. I also take a couple of drops of CBD if I feel stressed or overwhelmed and it calms me down. Highly recommend this CBD oil.
Runa WynekenRuna Wyneken
11:58 28 Sep 22
Love this product and the brand! Totally recommend it! Cleanest CBD out there!
Sven HurksSven Hurks
10:33 15 Jun 22
I have been using LAYV CBD for over one year, improving my sleep quality significantly.
Maria Mora GarciaMaria Mora Garcia
13:12 30 Apr 22
Excellent.I really like this cbd oil.
C. R.C. R.
21:44 25 Mar 22
After trying several other CBD oils, I've found my favourite. LAYV's cbd oil helps me with sleep and menstrual pain, taste is the best I've tried, great quality flask/packaging... Support is fast, professional and very helpful for any question! Even a handwritten note when you order from them!! Solid throughout. A CBD brand that's here to stay, finally!
Caspar de KlerCaspar de Kler
13:18 17 Apr 24
Top kwaliteit, goede klantenservice
14:01 13 Mar 24
Ik heb de cbd olie gekocht op aanraden van vriendin die er heel erg tevreden over was. Ik vind het fijne olie! Ik merk niet megaveel van de effecten maar ik slaap wel iets beter sinds ik het gebruik dus ik ben tevreden :)
Diewertje van BavelDiewertje van Bavel
20:41 07 Feb 24
Geweldig product. Het helpt me bij mijn pijn en stressklachten. Ook slaap ik er een stuk beter door. Ik kan dit product echt aanraden!
Lilian DibbetsLilian Dibbets
16:28 15 Jan 24
Dit is echt een fantastisch product. Ik was altijd een goede slaper maar met deze CBD olie (20%) slaap ik veel dieper en wordt ik uitgerust wakker. Daarnaast helpt het mijn zenuwstelsel tot rust te brengen en ben ik door de dag heen veel rustiger en gefocussed. Ik raad iedereen dit product aan voor een kalm zenuwustelsel en een goede gezondheid. Zie het als een voedingsupplement die niet mag ontbreken in deze hectische westerse wereld waar we in leven.
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We (my wife and I) love this product. We use it to relax and unwind in the evening for a better night's sleep. We both noticed that our stress levels dropped significantly.....
Ferdinand van der Neut
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LAYV's CBD oil provides more structure to my thinking throughout the day. In the process, it greatly improves the quality of my sleep with just a few drops a day. Can't say anything but highly recommended!
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I really love this product! It helps me with anxiety, confidence, relaxation and pain relief. My advice would be to take a few drops every day so that it can be absorbed into the bloodstream and you can enjoy the long-term benefits. 1000% recommended!
Kas van Vliet
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Calming without the risk of paranoia. I used to reach for cannabis on very sporadic frequencies to unload from a busy existence as an entrepreneur and journalist, but smoking weed or hash was always a gamble for me: 50/50 chance of a slightly paranoid experience that exacerbated stress rather than reduced it. For me, this is a good substitute that allows me to relax physically and mentally, but sin negative high. But don't think of it as a panacea; you have to create a peaceful environment for it to really come into its own.
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I bought a bottle at Jumbo today, because I am always very cramped and tense, and suffer a lot from headaches and stress..... i must say i am pleasantly surprised, that t is sold by jumbo, and that t works! Definitely worth a try! Am curious if there will be more products from you.
H. Paulus de Groot
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Have been using this for months for chronic pain in my shoulder, and it just works!
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The product has a good taste despite its high concentration (500 mg). It helps me with stress, sleep and pain.
Willem Spoor
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Helps excellent against osteoarthritis pain
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Good product and good minty taste
J.A. Worskasan
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Layv Cbd oil makes me calmer, it helps me with livedo reticularis on my legs, after using it my legs become normal again. I used CBD from other brands and Layv Cbd oil is definitely the highest quality product.