Cannabidiol (CBD) and its analogs: A review of their effects on inflammation

Although it was discovered early on, CBD has become a major area of research only in recent years. In particular, its biological Table 1 Anti-inflammatory actions of CBD Response Model Reference Reduces immune response Rats subjected to pneumococcal meningitis 59 Prevents experimental colitis Murine model of colitis 52 Reduced iNOS and IL-1b expression Mouse model of Alzheimer’s disease 31,43 Reduces b-amyloid-induced neuroinflammation Cultured astrocytes 43 TNF-a and IL-1b levels reduced Murine collagen-induced arthritis 9 Decreases in PGE2 plasma levels Carrageenan paw injection in the rat 28 Reduced the extent of colitis TNB mouse model of colitis 53 Inhibition of neutrophil chemotaxis Human neutrophil migration 54 Effects on NF-jB, MAPK, ICAM-1, VCAM-1, TNF-a Mouse model of type I diabetic cardiomyopathy 55 Enhanced IFN-c and IL-2 production Mouse splenocytes 57 Exacerbates LPS-induced pulmonary inflammation Pulmonary inflammation in C57BL/6 mice 58 Reduced the TNF-a level in the frontal cortex Pneumococcal meningitis in rats 59 Decreases hepatic ischemia-reperfusion (I/R) injury Mouse model of hepatic I/R 61 Reduced LPS-induced increase in TNFa and COX-2 Mouse model of sepsis-related encephalitis 62 Reduced effects of autoimmune encephalomyelitis Immunized C57BL/6 mice 34,63 Reduces inflammation in acute lung injury (ALI) Mouse model of lipopolysaccharide-induced ALI 64,18 1384 S. Burstein / Bioorg. Med. Chem. 23 (2015) 1377–1385 actions are a topic of many interesting reports that suggest possible therapeutic applications. Included are its anti inflammatory actions in a variety of preclinical models (Table 1). Some examples are experimental colitis, collagen-induced arthritis, b-amyloid-induced neuroinflammation, neutrophil chemotaxis, hepatic ischemiareperfusion (I/R) injury, autoimmune encephalomyelitis, acute lung injury (ALI), etc. These and others need to be pursued in human trials with a view toward clinical applications where CBD’s absence of psychotropic effects and other adverse events offers a major advantage over other cannabinoids

What LAYV® users say

ghm lammersghm lammers
20:13 12 May 24
Trustworthy !
Caspar de KlerCaspar de Kler
13:18 17 Apr 24
Top quality, good customer service
Loes-chanLoes-chan
14:01 13 Mar 24
I bought the CBD oil on the recommendation of a friend who was very satisfied with it. I think it's a nice oil! I don't notice much of the effects, but I do sleep a little better since I started using it so I'm satisfied :)
Diewertje van BavelDiewertje van Bavel
20:41 07 Feb 24
Great product. It helps me with my pain and stress complaints. It also makes me sleep a lot better. I can really recommend this product!
Lilian DibbetsLilian Dibbets
16:28 15 Jan 24
This really is a fantastic product. I was always a good sleeper, but with this CBD oil (20%) I sleep much deeper and wake up rested. In addition, it helps to calm my nervous system and I am much calmer and focused throughout the day. I recommend this product to everyone for a calm nervous system and good health. Think of it as a nutritional supplement that should not be missing in this hectic Western world we live in.
Richard LemmensRichard Lemmens
10:44 18 Dec 23
What a fantastic product. For several months now we have been using the LAYV CBD variant 20% daily before going to sleep as a routine. As young parents, sleep is sacred to us, but with children this is sometimes lacking. By using the 20% variant, we both notice that we sleep much deeper, making us more rested in the morning.We also use the drug when we experience a stressful situation. By using a few drops, we quickly notice that we become calmer and can continue with our busy daily work lives.Previously used products from other brands, but these do not provide a pleasant mouthfeel and the taste is not as mild as the LAYV variant.
Fabiana FiniFabiana Fini
17:41 04 Dec 23
Liesbeth MekkeringLiesbeth Mekkering
10:14 14 Nov 23
I slept wonderfully thanks to LAYV, I couldn't live without it
Tahsin BulbulTahsin Bulbul
07:22 30 Oct 23
Juan Calixto morelloJuan Calixto morello
13:13 29 Oct 23
I recently no longer suffer from sleepless nights thanks to layv!
Nikos VasilatosNikos Vasilatos
17:19 25 Jun 23
Happy with the product, the responsiveness of the Layv team and the smooth delivery. Recommended!
Michal SokolowskiMichal Sokolowski
21:05 15 Jun 23
Excellent oils, quick contact if you have any questions, fast shipping abroad, I recommend! Greetings from Poland!
Charles PierrepontCharles Pierrepont
17:31 05 Apr 23
The LAYV CBD extract tastes and feels very clean. Dealing with the team at LAYV has been a pleasure. For someone who travels a lot, the clean CBD extract absolutely helps to unwind at the end of a long day.
Clare La Feber-ToolisClare La Feber-Toolis
06:24 30 Mar 23
I used the 5% LAYV CBD to manage pain from the symptoms of arthritis and it really helps. It has completely reduced the need for strong painkillers which is great. I also take a couple of drops of CBD if I feel stressed or overwhelmed and it calms me down. Highly recommend this CBD oil.
Runa WynekenRuna Wyneken
11:58 28 Sep 22
Love this product and the brand! Totally recommend it! Cleanest CBD out there!
Sven HurksSven Hurks
10:33 15 Jun 22
I have been using LAYV CBD for over one year, improving my sleep quality significantly.
Maria Mora GarciaMaria Mora Garcia
13:12 30 Apr 22
Excellent.I really like this cbd oil.
C. R.C. R.
21:44 25 Mar 22
After trying several other CBD oils, I've found my favourite. LAYV's cbd oil helps me with sleep and menstrual pain, taste is the best I've tried, great quality flask/packaging... Support is fast, professional and very helpful for any question! Even a handwritten note when you order from them!! Solid throughout. A CBD brand that's here to stay, finally!
ghm lammersghm lammers
20:13 12 May 24
Betrouwbaar !
Caspar de KlerCaspar de Kler
13:18 17 Apr 24
Top kwaliteit, goede klantenservice
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Tom
@tomdima0711
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We (my wife and I) love this product. We use it to relax and unwind in the evening for a better night's sleep. We both noticed that our stress levels dropped significantly.....
Ferdinand van der Neut
@ketschi.a
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LAYV's CBD oil provides more structure to my thinking throughout the day. In the process, it greatly improves the quality of my sleep with just a few drops a day. Can't say anything but highly recommended!
Sophie
@carolinesophiew
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I really love this product! It helps me with anxiety, confidence, relaxation and pain relief. My advice would be to take a few drops every day so that it can be absorbed into the bloodstream and you can enjoy the long-term benefits. 1000% recommended!
Kas van Vliet
@kasvanvliet
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Calming without the risk of paranoia. I used to reach for cannabis on very sporadic frequencies to unload from a busy existence as an entrepreneur and journalist, but smoking weed or hash was always a gamble for me: 50/50 chance of a slightly paranoid experience that exacerbated stress rather than reduced it. For me, this is a good substitute that allows me to relax physically and mentally, but sin negative high. But don't think of it as a panacea; you have to create a peaceful environment for it to really come into its own.
Alexandra
@angelique_acc
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I bought a bottle at Jumbo today, because I am always very cramped and tense, and suffer a lot from headaches and stress..... i must say i am pleasantly surprised, that t is sold by jumbo, and that t works! Definitely worth a try! Am curious if there will be more products from you.
H. Paulus de Groot
@hnkdgrt
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Have been using this for months for chronic pain in my shoulder, and it just works!
jl_arellanocamacho
@jl_arellanocamacho
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The product has a good taste despite its high concentration (500 mg). It helps me with stress, sleep and pain.
Willem Spoor
@w.spoor35
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Helps excellent against osteoarthritis pain
Maria
@maria.mgj
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Good product and good minty taste
J.A. Worskasan
@jaworskasan
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Layv Cbd oil makes me calmer, it helps me with livedo reticularis on my legs, after using it my legs become normal again. I used CBD from other brands and Layv Cbd oil is definitely the highest quality product.
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