Cannabidiol use with our patient has shown promising results in controlling the pain and concomitant mood disorder. Given our experience and the growing body of evidence for the efficacy of CBD in treating patients with multiple chronic pain conditions, it should be considered as a treatment option in the management of this patient group, especially when conventional pain medications have failed or were not well-tolerated. CBD also seems to have a positive effect on the psychosocial pain component of NF1. Nevertheless, more research targeted at understanding the etiology of the pain in NF1 and also more clinical trials using CBD for NF1 are still needed.