Cannabidiol Counteracts the Psychotropic Side-Effects of ?-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1-2 Phosphorylation

Evidence suggests that the phytocannabinoids ?-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) differentially regulate salience attribution and psychiatric risk. The ventral hippocampus (vHipp) relays emotional salience via control of dopamine (DA) neuronal activity states, which are dysregulated in psychosis and schizophrenia….These results identify vHipp pERK1-2 signaling as a critical neural nexus point mediating THC-induced affective disturbances and suggest a potential mechanism by which CBD may counteract the psychotomimetic and psychotropic side effects of THC.

What LAYV® users say

Loes-chanLoes-chan
14:01 13 Mar 24
I bought the CBD oil on the recommendation of a friend who was very satisfied with it. I think it's a nice oil! I don't notice much of the effects, but I do sleep a little better since I started using it so I'm satisfied :)
Diewertje van BavelDiewertje van Bavel
20:41 07 Feb 24
Great product. It helps me with my pain and stress complaints. It also makes me sleep a lot better. I can really recommend this product!
Lilian DibbetsLilian Dibbets
16:28 15 Jan 24
This really is a fantastic product. I was always a good sleeper, but with this CBD oil (20%) I sleep much deeper and wake up rested. In addition, it helps to calm my nervous system and I am much calmer and focused throughout the day. I recommend this product to everyone for a calm nervous system and good health. Think of it as a nutritional supplement that should not be missing in this hectic Western world we live in.
Richard LemmensRichard Lemmens
10:44 18 Dec 23
What a fantastic product. For several months now we have been using the LAYV CBD variant 20% daily before going to sleep as a routine. As young parents, sleep is sacred to us, but with children this is sometimes lacking. By using the 20% variant, we both notice that we sleep much deeper, making us more rested in the morning.We also use the drug when we experience a stressful situation. By using a few drops, we quickly notice that we become calmer and can continue with our busy daily work lives.Previously used products from other brands, but these do not provide a pleasant mouthfeel and the taste is not as mild as the LAYV variant.
Fabiana FiniFabiana Fini
17:41 04 Dec 23
Liesbeth MekkeringLiesbeth Mekkering
10:14 14 Nov 23
I slept wonderfully thanks to LAYV, I couldn't live without it
Tahsin BulbulTahsin Bulbul
07:22 30 Oct 23
Juan Calixto morelloJuan Calixto morello
13:13 29 Oct 23
I recently no longer suffer from sleepless nights thanks to layv!
Nikos VasilatosNikos Vasilatos
17:19 25 Jun 23
Happy with the product, the responsiveness of the Layv team and the smooth delivery. Recommended!
Michal SokolowskiMichal Sokolowski
21:05 15 Jun 23
Excellent oils, quick contact if you have any questions, fast shipping abroad, I recommend! Greetings from Poland!
Charles PierrepontCharles Pierrepont
17:31 05 Apr 23
The LAYV CBD extract tastes and feels very clean. Dealing with the team at LAYV has been a pleasure. For someone who travels a lot, the clean CBD extract absolutely helps to unwind at the end of a long day.
Clare La Feber-ToolisClare La Feber-Toolis
06:24 30 Mar 23
I used the 5% LAYV CBD to manage pain from the symptoms of arthritis and it really helps. It has completely reduced the need for strong painkillers which is great. I also take a couple of drops of CBD if I feel stressed or overwhelmed and it calms me down. Highly recommend this CBD oil.
Runa WynekenRuna Wyneken
11:58 28 Sep 22
Love this product and the brand! Totally recommend it! Cleanest CBD out there!
Sven HurksSven Hurks
10:33 15 Jun 22
I have been using LAYV CBD for over one year, improving my sleep quality significantly.
Maria Mora GarciaMaria Mora Garcia
13:12 30 Apr 22
Excellent.I really like this cbd oil.
C. R.C. R.
21:44 25 Mar 22
After trying several other CBD oils, I've found my favourite. LAYV's cbd oil helps me with sleep and menstrual pain, taste is the best I've tried, great quality flask/packaging... Support is fast, professional and very helpful for any question! Even a handwritten note when you order from them!! Solid throughout. A CBD brand that's here to stay, finally!
Loes-chanLoes-chan
14:01 13 Mar 24
Ik heb de cbd olie gekocht op aanraden van vriendin die er heel erg tevreden over was. Ik vind het fijne olie! Ik merk niet megaveel van de effecten maar ik slaap wel iets beter sinds ik het gebruik dus ik ben tevreden :)
Diewertje van BavelDiewertje van Bavel
20:41 07 Feb 24
Geweldig product. Het helpt me bij mijn pijn en stressklachten. Ook slaap ik er een stuk beter door. Ik kan dit product echt aanraden!
Lilian DibbetsLilian Dibbets
16:28 15 Jan 24
Dit is echt een fantastisch product. Ik was altijd een goede slaper maar met deze CBD olie (20%) slaap ik veel dieper en wordt ik uitgerust wakker. Daarnaast helpt het mijn zenuwstelsel tot rust te brengen en ben ik door de dag heen veel rustiger en gefocussed. Ik raad iedereen dit product aan voor een kalm zenuwustelsel en een goede gezondheid. Zie het als een voedingsupplement die niet mag ontbreken in deze hectische westerse wereld waar we in leven.
Richard LemmensRichard Lemmens
10:44 18 Dec 23
Wat een fantastisch product. Sinds enkele maanden gebruiken wij dagelijks voor het slapen de LAYV CBD variant 20% als routine. Als jonge ouders is slaap voor ons namelijk heilig, met kinderen schiet dit er nog wel eens bij in. Door het gebruik van de 20% variant merken wij beiden dat we veel dieper slapen waardoor we meer uitgerust zijn in de ochtend.Ook wordt het middel door ons gebruikt als we een stress situatie ervaren. Door het gebruiken van een aantal druppels merken wij snel dat we rustiger worden en zo weer lekker door kunnen gaan met ons dagelijkse drukke werkleven.Voorheen producten gebruikt van overige merken maar deze geven niet een prettig mondgevoel en de smaak is niet zo mild als de LAYV variant.
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Tom
@tomdima0711
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We (my wife and I) love this product. We use it to relax and unwind in the evening for a better night's sleep. We both noticed that our stress levels dropped significantly.....
Ferdinand van der Neut
@ketschi.a
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LAYV's CBD oil provides more structure to my thinking throughout the day. In the process, it greatly improves the quality of my sleep with just a few drops a day. Can't say anything but highly recommended!
Sophie
@carolinesophiew
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I really love this product! It helps me with anxiety, confidence, relaxation and pain relief. My advice would be to take a few drops every day so that it can be absorbed into the bloodstream and you can enjoy the long-term benefits. 1000% recommended!
Kas van Vliet
@kasvanvliet
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Calming without the risk of paranoia. I used to reach for cannabis on very sporadic frequencies to unload from a busy existence as an entrepreneur and journalist, but smoking weed or hash was always a gamble for me: 50/50 chance of a slightly paranoid experience that exacerbated stress rather than reduced it. For me, this is a good substitute that allows me to relax physically and mentally, but sin negative high. But don't think of it as a panacea; you have to create a peaceful environment for it to really come into its own.
Alexandra
@angelique_acc
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I bought a bottle at Jumbo today, because I am always very cramped and tense, and suffer a lot from headaches and stress..... i must say i am pleasantly surprised, that t is sold by jumbo, and that t works! Definitely worth a try! Am curious if there will be more products from you.
H. Paulus de Groot
@hnkdgrt
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Have been using this for months for chronic pain in my shoulder, and it just works!
jl_arellanocamacho
@jl_arellanocamacho
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The product has a good taste despite its high concentration (500 mg). It helps me with stress, sleep and pain.
Willem Spoor
@w.spoor35
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Helps excellent against osteoarthritis pain
Maria
@maria.mgj
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Good product and good minty taste
J.A. Worskasan
@jaworskasan
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Layv Cbd oil makes me calmer, it helps me with livedo reticularis on my legs, after using it my legs become normal again. I used CBD from other brands and Layv Cbd oil is definitely the highest quality product.
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