Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System – PMC

Notably, the best-studied non-psychotropic pCB, i.e., CBD (10 ?M), was found to exert complex anti-acne effects by normalizing several pro-acne agents-induced excessive SLG, and by exerting anti-proliferative and anti-inflammatory actions, without influencing homeostatic SLG or viability of human sebocytes. Importantly, the lipostatic and anti-proliferative effects were found to be mediated by the TRPV4?[Ca2+]IC??ERK1/2 MAPK? and nuclear receptor interacting protein 1 (NRIP1, a.k.a. RIP140)? signaling pathway, whereas the anti-inflammatory actions were coupled to the (most likely indirect) activation of the adenosine A2A receptor?cAMP??tribbles homolog 3 (TRIB3)??p65-NF-?B? pathway [120]. This, together with the fact that CBD was shown to suppress proliferation [122] and differentiation [59] of human keratinocytes, and to exert potent anti-bacterial effects [123], collectively argue that it may be an efficient anti-acne agent in vivo as well. This concept was further supported by a small, single-blind, split-face study, in which a cream containing 3% Cannabis seed extract was applied twice daily to the cheeks of patients for 12 weeks. The treatment was found to be efficient in reducing sebum production and erythema compared to the vehicle treated side [124]. Moreover, a synthetic CBD containing special topical formulation (“BTX 1503”) exhibited promising anti-acne potential in a small phase Ib clinical trial [125], and its efficacy is now being tested in a randomized, double-blind, vehicle-controlled phase II clinical study (ClinicalTrials.gov ID: NCT03573518). Last, but not least, it should also be noted that effects of several other non-psychotropic pCBs, namely CBC, CBDV, CBG, CBGV and THCV were also assessed in human sebocytes. This latter study found an intriguing functional heterogeneity between the tested pCBs, with CBC, CBDV and most especially THCV behaving in a “CBD-like” manner (potent complex anti-acne effects in vitro), whereas CBG and CBGV being more “eCB-like” substances (slight, but significant promotion of SLG together with potent anti-inflammatory activity) [126]. Although the exact impact of CBG and CBGV on the sebaceous lipidome remains to be tested in future studies, the available evidence suggests that, similar to the aforementioned EMT-inhibitors VDM11 and AM404, they might have therapeutic value in dryness- and inflammation-accompanied skin diseases. The putative SG-related translational potential of cannabinoid signaling is summarized in Table 1.

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14:01 13 Mar 24
I bought the CBD oil on the recommendation of a friend who was very satisfied with it. I think it's a nice oil! I don't notice much of the effects, but I do sleep a little better since I started using it so I'm satisfied :)
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16:28 15 Jan 24
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Richard LemmensRichard Lemmens
10:44 18 Dec 23
What a fantastic product. For several months now we have been using the LAYV CBD variant 20% daily before going to sleep as a routine. As young parents, sleep is sacred to us, but with children this is sometimes lacking. By using the 20% variant, we both notice that we sleep much deeper, making us more rested in the morning.We also use the drug when we experience a stressful situation. By using a few drops, we quickly notice that we become calmer and can continue with our busy daily work lives.Previously used products from other brands, but these do not provide a pleasant mouthfeel and the taste is not as mild as the LAYV variant.
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The LAYV CBD extract tastes and feels very clean. Dealing with the team at LAYV has been a pleasure. For someone who travels a lot, the clean CBD extract absolutely helps to unwind at the end of a long day.
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06:24 30 Mar 23
I used the 5% LAYV CBD to manage pain from the symptoms of arthritis and it really helps. It has completely reduced the need for strong painkillers which is great. I also take a couple of drops of CBD if I feel stressed or overwhelmed and it calms me down. Highly recommend this CBD oil.
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11:58 28 Sep 22
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10:33 15 Jun 22
I have been using LAYV CBD for over one year, improving my sleep quality significantly.
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13:12 30 Apr 22
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C. R.C. R.
21:44 25 Mar 22
After trying several other CBD oils, I've found my favourite. LAYV's cbd oil helps me with sleep and menstrual pain, taste is the best I've tried, great quality flask/packaging... Support is fast, professional and very helpful for any question! Even a handwritten note when you order from them!! Solid throughout. A CBD brand that's here to stay, finally!
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20:13 12 May 24
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Top kwaliteit, goede klantenservice
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Tom
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We (my wife and I) love this product. We use it to relax and unwind in the evening for a better night's sleep. We both noticed that our stress levels dropped significantly.....
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LAYV's CBD oil provides more structure to my thinking throughout the day. In the process, it greatly improves the quality of my sleep with just a few drops a day. Can't say anything but highly recommended!
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I really love this product! It helps me with anxiety, confidence, relaxation and pain relief. My advice would be to take a few drops every day so that it can be absorbed into the bloodstream and you can enjoy the long-term benefits. 1000% recommended!
Kas van Vliet
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Calming without the risk of paranoia. I used to reach for cannabis on very sporadic frequencies to unload from a busy existence as an entrepreneur and journalist, but smoking weed or hash was always a gamble for me: 50/50 chance of a slightly paranoid experience that exacerbated stress rather than reduced it. For me, this is a good substitute that allows me to relax physically and mentally, but sin negative high. But don't think of it as a panacea; you have to create a peaceful environment for it to really come into its own.
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I bought a bottle at Jumbo today, because I am always very cramped and tense, and suffer a lot from headaches and stress..... i must say i am pleasantly surprised, that t is sold by jumbo, and that t works! Definitely worth a try! Am curious if there will be more products from you.
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Have been using this for months for chronic pain in my shoulder, and it just works!
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The product has a good taste despite its high concentration (500 mg). It helps me with stress, sleep and pain.
Willem Spoor
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Helps excellent against osteoarthritis pain
Maria
@maria.mgj
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Good product and good minty taste
J.A. Worskasan
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Layv Cbd oil makes me calmer, it helps me with livedo reticularis on my legs, after using it my legs become normal again. I used CBD from other brands and Layv Cbd oil is definitely the highest quality product.
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