The current results of cannabinoids effects on neurogenesis are encouraging, and it is expectable that the amount of evidence continues to increase in the future with other experiments. The phytocannabinoid CBD proved its versatility in the treatment, increasing neurogenesis in the models where it was tested. Moreover, it is known to have anxiolytic and anti-inflammatory properties, which can be welcome effects in pathologies such as AD or PD. Regarding synthetic compounds, WIN-55212-2 seems a good candidate for its capacity to activate both CBs receptors, but its effects on pure neurogenesis in pathological conditions are not so prominent. VCE-003.2 and AM-12441 administration proved to have a more direct outcome in neurogenesis. However, CBD exerts its effect, also, on PPAR?, so it is probably the current best candidate for a neurogenesis-based therapy. Further experiments are necessary to evaluate side effects and to standardize the treatment.