Cannabinoids, Endocannabinoids and Sleep – PMC

A long-term study of sleep quality assessed CBD actions using a common self-report instrument found a modest improvement in sleep, and more patients with improved sleep compared to poorer sleep (Shannon et al., 2019). Most studies on the effects of cannabinoids in sleep, and in general, have focused on the effects of purified THC, or cannabis preparations with relatively high levels of THC compared to other phytocannabinoids. However, recent interest in therapeutic roles for CBD has ushered in further studies focusing on CBD, including its effects on sleep. In one study, mixed effects of combined THC and CBD have were reported, with THC generally increasing sedation and CBD having opposing, wake-enhancing effects (Nicholson et al., 2004). A long-term study of sleep quality assessed CBD actions using a common self-report instrument found a modest improvement in sleep, and more patients with improved sleep compared to poorer sleep (Shannon et al., 2019). Notably, a study using the Sativex extract formulation (containing approximately equal ~2 mg doses of THC and CBD) to examine sleep in subjects with pain-related sleep disturbances (Russo et al., 2007) reported improved sleep with no evidence of tolerance to the drug action. Thus, there may be cannabis formulations that support sustained sleep improvement. A recent controlled clinical study assessing the acute pharmacodynamic effects of 100 mg of CBD or CBD-dominant cannabis found that vapor inhalation of the latter increased subjective sleepiness. The investigators noted that CBD alone did not have significant effects on sleepiness, so possibly the effects of the CBD-dominant cannabis were due to the relatively small amounts of THC in their CBD-dominant cannabis preparation (Spindle et al., 2020). Indeed the amount of THC in their case was 3.7 mg, a similar concentration as found in many “full spectrum,” <0.3% THC, commercial CBD products (Corroon and Kight, 2018), indicating further controlled research into the physiological effects of these commercial products is necessary. It is still unclear whether acute administration of this relatively low dose of THC alone is enough to produce sleepiness, or whether it has synergistic effects with CBD and other phytocannabinoids in the strain of CBD-dominant cannabis used in this study.

What LAYV® users say

Nikos VasilatosNikos Vasilatos
17:19 25 Jun 23
Happy with the product, the responsiveness of the Layv team and the smooth delivery. Recommended!
Michal SokolowskiMichal Sokolowski
21:05 15 Jun 23
Excellent oils, quick contact if you have any questions, fast shipping abroad, I recommend! Greetings from Poland!
Charles PierrepontCharles Pierrepont
17:31 05 Apr 23
The LAYV CBD extract tastes and feels very clean. Dealing with the team at LAYV has been a pleasure. For someone who travels a lot, the clean CBD extract absolutely helps to unwind at the end of a long day.
Clare La Feber-ToolisClare La Feber-Toolis
06:24 30 Mar 23
I used the 5% LAYV CBD to manage pain from the symptoms of arthritis and it really helps. It has completely reduced the need for strong painkillers which is great. I also take a couple of drops of CBD if I feel stressed or overwhelmed and it calms me down. Highly recommend this CBD oil.
Runa WynekenRuna Wyneken
11:58 28 Sep 22
Love this product and the brand! Totally recommend it! Cleanest CBD out there!
Sven HurksSven Hurks
10:33 15 Jun 22
I have been using LAYV CBD for over one year, improving my sleep quality significantly.
Maria Mora GarciaMaria Mora Garcia
13:12 30 Apr 22
Excellent.I really like this cbd oil.
C. R.C. R.
21:44 25 Mar 22
After trying several other CBD oils, I've found my favourite. LAYV's cbd oil helps me with sleep and menstrual pain, taste is the best I've tried, great quality flask/packaging... Support is fast, professional and very helpful for any question! Even a handwritten note when you order from them!! Solid throughout. A CBD brand that's here to stay, finally!
Read More
We (my wife and I) love this product. We use it to relax and unwind in the evening for a better night's sleep. We both noticed that our stress levels dropped significantly.....
Ferdinand van der Neut
Read More
LAYV's CBD oil provides more structure to my thinking throughout the day. In the process, it greatly improves the quality of my sleep with just a few drops a day. Can't say anything but highly recommended!
Read More
I really love this product! It helps me with anxiety, confidence, relaxation and pain relief. My advice would be to take a few drops every day so that it can be absorbed into the bloodstream and you can enjoy the long-term benefits. 1000% recommended!
Kas van Vliet
Read More
Calming without the risk of paranoia. I used to reach for cannabis on very sporadic frequencies to unload from a busy existence as an entrepreneur and journalist, but smoking weed or hash was always a gamble for me: 50/50 chance of a slightly paranoid experience that exacerbated stress rather than reduced it. For me, this is a good substitute that allows me to relax physically and mentally, but sin negative high. But don't think of it as a panacea; you have to create a peaceful environment for it to really come into its own.
Read More
I bought a bottle at Jumbo today, because I am always very cramped and tense, and suffer a lot from headaches and stress..... i must say i am pleasantly surprised, that t is sold by jumbo, and that t works! Definitely worth a try! Am curious if there will be more products from you.
H. Paulus de Groot
Read More
Have been using this for months for chronic pain in my shoulder, and it just works!
Read More
The product has a good taste despite its high concentration (500 mg). It helps me with stress, sleep and pain.
Willem Spoor
Read More
Helps excellent against osteoarthritis pain
Read More
Good product and good minty taste
J.A. Worskasan
Read More
Layv Cbd oil makes me calmer, it helps me with livedo reticularis on my legs, after using it my legs become normal again. I used CBD from other brands and Layv Cbd oil is definitely the highest quality product.