Our results suggest that the use of a combination of strategies could allow for greater therapeutic efficacy when using CBDs for cancer treatment. The in vitro study results showing synergistic outcomes when using CBDs in combination with RT are in consonance with previous work highlighted in recent reviews (1, 2). In one such previous study, synergy was observed in vivo when using RT with CBDs in the treatment of brain tumors, in a glioma model (26). Over the years, different reports have advocated for investigations of combination therapy approaches where such synergies could be established toward clinical translation (1, 13).